Indima ephawulekayo ye-Hyperbaric Oxygen Therapy kwiMpilo ye-Cardiovascular

Ukukhulula amandla oNikezo lwe-Oxygen yePhysical

Uphando lubonisa ukuba ngaphakathi kwegumbi le-hyperbaric kwi-atmospheres ye-2 yoxinzelelo (i-hyperbaric chamber 2 ata), i-solubility ye-oksijini ifikelela kumaxesha alishumi ngaphezu koxinzelelo oluqhelekileyo. Oku kufunxeka okuphuculweyo kwenza ioksijini ingene kwiindawo ezithinteleyo ukuhamba kwegazi, ekugqibeleni ihambise "ioksijini engxamisekileyo" kwintliziyo ye-ischemic okanye kwizicubu zobuchopho. Lo matshini ungqina ukuba luncedo ngakumbi kubantu abaphethwe yi-hypoxia engapheliyo ngenxa yeemeko ezinje nge-coronary artery stenosis kunye ne-cerebral arteriosclerosis, enikezela isiqabu ngokukhawuleza kwiimpawu ezinjengokuqina kwesifuba kunye nesiyezi.

 

Ukukhuthaza i-Angiogenesiskunye noKwakha kwakhona iiChaneli zeOxygen

Unyango lwe-oxygen ye-hyperbaric alubhekiseli kuphela kwiimfuno ezikhawulezayo kodwa lukhuthaza ukubuyiswa kwexesha elide ngokukhuthaza ukukhululwa kwe-vascular endothelial growth factor (VEGF). Le nkqubo inceda ekuqulunqweni kwe-collateral circulation kwiindawo ze-ischemic, ukuphucula kakhulu ukunikezelwa kwegazi entliziyweni nasengqondweni. Uphononongo lubonise ukuba emva kweeseshoni ze-HBOT ze-20, izigulane ze-coronary artery disease zibone ukwanda okuphawulekayo kwi-myocardial microcirculation ngama-30% ukuya kuma-50%.

 

I-Anti-inflammatory kunye ne-Antioxidant Effects: Ukukhusela Umsebenzi weSeli

Ukongeza kwisakhono sayo se-oxygen, i-HBOT isebenzisa i-anti-inflammatory kunye ne-antioxidant iziphumo, iyenza ibaluleke kakhulu ekukhuseleni intliziyo kunye nokusebenza kweeseli zengqondo. Uphando lubonisa ukuba unyango lunokunciphisa iindlela ezivuthayo ezifana ne-NF-κB, ukunciphisa ukukhululwa kwezinto eziphazamisayo ezifana ne-TNF-α kunye ne-IL-6. Ngaphezu koko, ukuphuculwa komsebenzi we-superoxide dismutase (SOD) kunceda ukuphelisa ii-radicals zamahhala, ukunciphisa umonakalo we-endothelial kunye nokubonelela ngempembelelo yokukhusela kwiimeko ezingapheliyo ezivuthayo ezifana ne-atherosclerosis kunye neenguqu ezinxulumene nesifo seswekile.

 

Izicelo zeklinikhi ye-Hyperbaric Oxygen kwiZifo ze-Cardiovascular

Iziganeko ze-Ischemic ezibukhali

I-Myocardial Infarction: Xa ilawulwa kunye ne-thrombolysis okanye unyango olungenelelayo, i-HBOT inokunciphisa ngokufanelekileyo i-myocardial cell apoptosis kunye nokunciphisa umngcipheko we-arrhythmias eyingozi.

I-Cerebral Infarction: Ukusetyenziswa kwangaphambili kwonyango lwe-hyperbaric oksijini kunokwandisa ukusinda kweeseli, ukunciphisa ubungakanani be-infarct, kunye nokuphucula umsebenzi we-neurological.

 

UkuBuyiselwa kweZifo eziNgapheliyo

I-Stable Coronary Artery Disease: Izigulane zihlala zifumana iimpawu eziphuculweyo ze-angina, ukunyuka kokunyamezela ukunyamezela, kunye nokunciphisa ukuxhomekeka kwiyeza ze-nitrate.

I-Rapid Atrial Arrhythmias (Uhlobo olucothayo): Ngemiphumo emibi ye-inotropic, i-HBOT inceda ukukhawuleza kwentliziyo, ukunciphisa ukusetyenziswa kwe-oksijini ye-myocardial, kunye nokuphucula iimeko ze-ischemic.

I-Hypertensive Heart Disease: Unyango lunciphisa i-viscosity yegazi kunye nokunciphisa i-hypertrophy ye-ventricular yasekhohlo, ngokufanelekileyo ukukhawuleza ukuqhubela phambili kwentliziyo.

I-Post-Stroke Sequelae: I-HBOT inceda ekuhlengahlengisweni kwe-synaptic, ukuphucula ukusebenza kweemoto kunye nobuchule bokuqonda.

 

Iprofayili yoKhuseleko lwe-Hyperbaric Oxygen Therapy

I-HBOT ngokubanzi ithathwa njengekhuselekile, eneziphumo ebezingalindelekanga ezincinci. Ezona nkxalabo ziphambili ziqhelekile kukungakhululeki koxinzelelo lwendlebe, olunokuthi luthotywe ngohlengahlengiso loxinzelelo. Nangona kunjalo, kukho ukuchasana okuthile, kubandakanywa ukopha okusebenzayo, i-pneumothorax engaphendulwanga, i-emphysema enzima, i-pulmonary bullae, kunye ne-heart block epheleleyo.

 

Amathemba ekamva: Ukusuka kuNyango ukuya kuThintelo

Uphando olukhulayo lubonisa amandla e-HBOT ekubambezelekeni kwenkqubo ye-atherosclerotic ngokuphucula i-vascular elasticity kunye nokunciphisa amanqanaba e-lipid yegazi. Oku kubeka ioksijini ye-hyperbaric njengenyathelo elisebenzayo lokulwa "i-hypoxia ethe cwaka," ngakumbi kubantu abaneempawu ezifana nesiyezi, ukuncipha kwenkumbulo, kunye nokuphuthelwa. Ngenkqubela phambili kunyango oluncediswa yi-AI kunye nezicelo ezitsha ezifana nonyango lwe-stem cell, i-HBOT kusenokwenzeka ukuba ikwincopho yokuba sisiseko solawulo lwempilo yentliziyo.

 

Ukuqukumbela

Unyango lwe-oksijeni ye-Hyperbaric luvelele njengesisombululo esithembisayo, esingenaso-pharmacological kwizifo ze-cardiovascular, ezakhiwe kwisiseko "sokunikezelwa kwe-oksijini yomzimba." Le ndlela ineendlela ezininzi, ukudibanisa ukulungiswa kwe-vascular, i-anti-inflammatory effects, kunye neenzuzo ze-antioxidant, zibonisa iingenelo ezinkulu kwiimeko ezingxamisekileyo kunye nokuvuselelwa okungapheliyo. Ngaphezu koko, ukusetyenziswa kwe-electrocardiograms (ECG) njengesalathisi esibucayi se-oxygenation kunye ne-ischemia inokusebenza njengobungqina obuxabisekileyo bekliniki obuxhasa ukusebenza kwe-HBOT. Ukukhetha i-HBOT ayikokukhetha nje unyango; kubonisa ukuzibophelela okukhawulezileyo ekulawuleni impilo yomntu kunye nokuphila kakuhle.