Indima Ephawulekayo Yonyango Lwe-Oxygen Ye-Hyperbaric kwiMpilo Yentliziyo

Ukukhulula Amandla Obonelelo Lweoksijini Yomzimba

Uphando lubonisa ukuba ngaphakathi kwigumbi eline-hyperbaric kwi-atmospheres ezimbini zoxinzelelo (igumbi eline-hyperbaric 2 ata), ukunyibilika kweoksijini kuphindwe kalishumi kunoko kuxinzelelo oluqhelekileyo. Oku kunyuswa komoya-mpilo kwenza ukuba ioksijini ingene kwiindawo ezihamba igazi ezivalekileyo, ekugqibeleni ihambise "ioksijini engxamisekileyo" kwintliziyo okanye kwizicubu zobuchopho. Le ndlela ingqineka iluncedo ngakumbi kubantu abanesifo se-hypoxia esingapheliyo ngenxa yeemeko ezifana ne-coronary artery stenosis kunye ne-cerebral arteriosclerosis, enika isiqabu ngokukhawuleza kwiimpawu ezifana nokuxinana kwesifuba kunye nesiyezi.

 

Ukukhuthaza i-Angiogenesiskunye noKwakha kwakhona iiTshitshi zeOksijini

Unyango lwe-hyperbaric oxygen alujongani neemfuno ezikhawulezileyo kuphela kodwa lukwakhuthaza ukuphinda uphile ixesha elide ngokuvuselela ukukhululwa kwe-vascular endothelial growth factor (VEGF). Le nkqubo inceda ekwakhiweni kokujikeleza kwegazi kwiindawo ezingasebenzi kakuhle, iphucula kakhulu ukunikezelwa kwegazi entliziyweni nasebuchotsheni. Izifundo zibonise ukuba emva kweeseshoni ezingama-20 ze-HBOT, izigulane ezine-coronary artery disease zibone ukwanda okumangalisayo kwe-myocardial microcirculation ngama-30% ukuya kuma-50%.

 

Iziphumo zokuchasana nokuvuvukala kunye ne-Antioxidant: Ukukhusela umsebenzi weseli

Ukongeza kwizakhono zayo zokungenisa ioksijini, i-HBOT inefuthe lokulwa nokuvuvukala kunye ne-antioxidant, nto leyo eyenza ukuba ibaluleke kakhulu ekukhuseleni ukusebenza kweeseli zentliziyo kunye nobuchopho. Uphando lubonisa ukuba unyango lunokuthintela iindlela zokuvuvukala ezifana ne-NF-κB, lunciphise ukukhululwa kwezinto ezibangela ukuvuvukala ezifana ne-TNF-α kunye ne-IL-6. Ngaphezu koko, ukuphuculwa komsebenzi we-superoxide dismutase (SOD) kunceda ekususeni ii-free radicals, kunciphisa umonakalo we-endothelial kwaye kubonelela ngesiphumo sokukhusela kwiimeko ezingapheliyo zokuvuvukala ezifana ne-atherosclerosis kunye notshintsho lwemithambo yegazi olunxulumene nesifo seswekile.

 

Izicelo zeKliniki ze-Hyperbaric Oxygen kwiZifo zeCardiovascular

Iziganeko ezibukhali ze-Ischemic

I-Myocardial Infarction: Xa isetyenziswa kunye ne-thrombolysis okanye unyango olungenelelayo, i-HBOT inokunciphisa ngempumelelo i-myocardial cell apoptosis kwaye inciphise umngcipheko we-malignant arrhythmias.

Ukufa kweCerebral: Ukusetyenziswa kwangoko konyango lwe-hyperbaric oxygen kunokwandisa ukusinda kweeseli, kunciphise ubungakanani be-infarct, kwaye kuphucule ukusebenza kwemithambo-luvo.

 

Ukuvuselelwa kweZifo eziNgapheliyo

Isifo seMithambo yeCoronary esiZinzileyo: Izigulana zihlala zifumana iimpawu eziphucukileyo ze-angina, ukunyamezela umthambo okwandileyo, kunye nokuxhomekeka okunciphileyo kumayeza e-nitrate.

I-Rapid Atrial Arrhythmias (Uhlobo olucothayo): Ngenxa yeziphumo ezimbi ze-inotropic, i-HBOT inceda ekunciphiseni izinga lentliziyo, ukunciphisa ukusetyenziswa kweoksijini ye-myocardial, kunye nokunciphisa iimeko ze-ischemic.

Isifo sentliziyo esinoxinzelelo lwegazi: Olu nyango lunciphisa ukuxinana kwegazi kwaye lunciphisa i-hypertrophy ye-ventricular yasekhohlo, nto leyo ethintela ngempumelelo ukuqhubela phambili kokusilela kwentliziyo.

I-Post-Stroke Sequelae: I-HBOT inceda ekuguquleni i-synaptic, ukuphucula ukusebenza kwe-motor kunye nobuchule bokuqonda.

 

Iprofayili yoKhuseleko lwe-Hyperbaric Oxygen Therapy

I-HBOT idla ngokuthathwa njengekhuselekileyo, ineziphumo ebezingalindelekanga ezincinci. Iingxaki eziphambili zihlala zikukungonwabi okuncinci kwengcinezelo yendlebe, okunokunciphisa ngokulungiswa koxinzelelo. Nangona kunjalo, kukho izinto ezithile ezingahambelaniyo, kubandakanya ukopha okusebenzayo, i-pneumothorax enganyangwanga, i-emphysema enzima, i-pulmonary bullae, kunye ne-complete heart block.

 

Amathemba Exesha Elizayo: Ukusuka Kunyango ukuya Kuthintelo

Uphando olusakhulayo lubonisa amandla e-HBOT ekulibaziseni inkqubo ye-atherosclerotic ngokuphucula ukuthamba kwemithambo yegazi kunye nokunciphisa amanqanaba e-lipid egazini. Oku kubeka i-hyperbaric oxygen njengendlela yokuthintela "ukungabikho koxinzelelo oluthe cwaka," ingakumbi kubantu abanengxaki yeempawu ezifana nesiyezi, ukudodobala kwenkumbulo, kunye nokungalali. Ngokuhambela phambili ekuphuculeni unyango oluncediswa yi-AI kunye nezicelo ezintsha ezifana nonyango lweeseli ze-stem, i-HBOT isenokuba yintsika yolawulo lwempilo yentliziyo.

 

Isiphelo

Unyango lwe-oksijini e-hyperbaric lubonakala njengesisombululo esithembisayo, esingesiso seyeza kwizifo zentliziyo, esakhelwe kwisiseko "sokunikezelwa kweoksijini ngokwasemzimbeni." Le ndlela ineenkcukacha ezininzi, edibanisa ukulungiswa kwemithambo yegazi, iziphumo zokulwa nokuvuvukala, kunye neenzuzo ze-antioxidant, ibonisa iingenelo ezinkulu kwiimeko ezingxamisekileyo ezingxamisekileyo kunye nokuvuselelwa okungapheliyo. Ngaphezu koko, ukusetyenziswa kwe-electrocardiograms (ECG) njengesalathisi esibuthathaka sokufakwa kweoksijini kunye ne-ischemia kunokusebenza njengobungqina obuxabisekileyo beklinikhi obuxhasa ukusebenza kwe-HBOT. Ukukhetha i-HBOT akukokukhetha nje unyango; kubonisa ukuzibophelela ekulawuleni impilo yakho kunye nokuphila kakuhle.