Intlungu yemisipha luvakalelo olubalulekileyo lwe-physiological olusebenza njengesilumkiso kwinkqubo yemithambo-luvo, olubonisa imfuneko yokukhuselwa kwingozi enokubakho evela kwiikhemikhali, ubushushu, okanye izinto ezibangela ukungasebenzi kakuhle. Nangona kunjalo, intlungu ye-pathological ingaba luphawu lwesifo, ingakumbi xa ibonakala ngokukhawuleza okanye iguquka ibe yintlungu engapheliyo—into eyahlukileyo enokubangela ukungonwabi okungapheliyo okanye okuqhubekayo kangangeenyanga okanye iminyaka. Intlungu engapheliyo ixhaphake kakhulu kuluntu ngokubanzi.
Uncwadi lwakutshanje lukhanyise ngemiphumo emihle yonyango lwe-hyperbaric oxygen (HBOT) kwiimeko ezahlukeneyo zentlungu engapheliyo, kubandakanya i-fibromyalgia syndrome, i-complex regional pain syndrome, i-myofascial pain syndrome, iintlungu ezinxulumene nezifo zemithambo yegazi, kunye neentloko ezibuhlungu. Unyango lwe-hyperbaric oxygen lungasetyenziselwa izigulana eziva iintlungu ezingaphenduliyo kwezinye iindlela zonyango, nto leyo egxininisa indima yalo ebalulekileyo ekulawuleni iintlungu.
Isifo seFibromyalgia
Isifo seFibromyalgia sibonakaliswa ziintlungu ezixhaphakileyo kunye nokuthamba kwiindawo ezithile zomzimba, ezaziwa ngokuba zii-tender points. I-pathophysiology echanekileyo ye-fibromyalgia ayikacaci; nangona kunjalo, kukho izizathu ezininzi ezinokubakho eziye zacetyiswa, kubandakanya ukungasebenzi kakuhle kwemisipha, ukuphazamiseka kokulala, ukungasebenzi kakuhle komzimba, kunye notshintsho lwe-neuroendocrine.
Utshintsho oluwohlokayo kwimisipha yabantu abane-fibromyalgia lubangelwa kukuncipha kokuhamba kwegazi kunye ne-hypoxia yendawo. Xa ukujikeleza kwegazi kuphazamisekile, ischemia elandelayo yehlisa amanqanaba e-adenosine triphosphate (ATP) kwaye yonyusa ubuninzi be-lactic acid. Unyango lwe-hyperbaric oxygen lunceda ukuhanjiswa kwe-oksijini ephuculweyo kwizicubu, okunokuthintela umonakalo wezicubu obangelwa yi-ischemia ngokunciphisa amanqanaba e-lactic acid kwaye kuncede ukugcina ubuninzi be-ATP. Kule nkalo, kukholelwa ukuba i-HBOT iyaukunciphisa iintlungu kwiindawo ezithambileyo ngokuphelisa i-hypoxia engaphakathi kwizicubu zemisipha.
I-Complex Regional Pain Syndrome (CRPS)
I-complex regional pain syndrome ibonakaliswa yintlungu, ukudumba, kunye nokungasebenzi kakuhle kwe-autonomic emva kokwenzakala kwezicubu ezithambileyo okanye imithambo-luvo, okuhlala kuhamba notshintsho kumbala wolusu kunye nobushushu. Unyango lwe-oksijini oluphezulu lubonakalise ithemba ekunciphiseni iintlungu kunye nokudumba kwesandla ngelixa luphucula ukuhamba kwesandla. Iziphumo ezilungileyo ze-HBOT kwi-CRPS zibangelwa kukukwazi kwayo ukunciphisa ukudumba okubangelwa yi-vasoconstriction ephezulu ye-oxygen,ivuselela umsebenzi we-osteoblast ocinezelweyo, kwaye inciphise ukwakheka kwezicubu ezine-fibrous.
Isifo seNtlungu yeMyofascial
I-Myofascial pain syndrome ibonakaliswa ngamanqaku abangela intshukumo kunye/okanye amanqaku abangelwa kukuhamba aquka iziganeko ezizimeleyo kunye nokuphazamiseka kokusebenza okunxulumene noko. Amanqaku abangela intshukumo afumaneka ngaphakathi kwamaqela aqinileyo ezicubu zemisipha, kwaye uxinzelelo olulula kula manqaku lunokubangela iintlungu ezithambileyo kwindawo echaphazelekayo kunye nentlungu edluliselweyo kude.
Ukulimala okubukhali okanye i-microtrauma ephindaphindayo kunokukhokelela ekulimaleni kwemisipha, okubangela ukuqhekeka kwe-sarcoplasmic reticulum kunye nokukhululwa kwe-calcium yangaphakathi kwiseli. Ukuqokelelana kwe-calcium kukhuthaza ukuxinana kwemisipha okuqhubekayo, okukhokelela kwi-ischemia ngokucinezelwa kwemithambo yegazi yendawo kunye nokwanda kwemfuno ye-metabolic. Oku kunqongophala kwe-oksijini kunye nezondlo kunciphisa ngokukhawuleza amanqanaba e-ATP yendawo, ekugqibeleni kuqhubeke nomjikelo ombi wentlungu. Unyango lwe-oksijini ye-hyperbaric luye lwafundwa kwimeko ye-ischemia yendawo, kwaye izigulana ezifumana i-HBOT zibike ukuba imingcele yentlungu yanda kakhulu kwaye zanciphisa amanqaku entlungu e-Visual Analog Scale (VAS). Olu phuculo lubangelwa kukusetyenziswa kwe-oksijini okwandisiweyo kwizicubu zemisipha, okuphula ngempumelelo umjikelo ombi wokuphelelwa yi-ATP kunye nentlungu ebangelwa yi-hypoxic.
Intlungu kwiZifo zeMithambo zePeripheral
Izifo zemithambo yegazi ejikeleze imithambo yegazi zihlala zibhekisa kwiimeko ze-ischemic ezichaphazela amalungu omzimba, ingakumbi imilenze. Iintlungu zokuphumla zibonisa isifo esinzima semithambo yegazi ejikeleze imithambo yegazi, esenzeka xa ukuhamba kwegazi okuphumlileyo ukuya kumalungu omzimba kuncitshiswa kakhulu. Unyango lwe-oksijini ye-hyperbaric lunyango oluqhelekileyo lwamanxeba angapheliyo kwizigulana ezinesifo semithambo yegazi ejikeleze imithambo yegazi. Ngelixa luphucula ukuphiliswa kwamanxeba, i-HBOT ikwanciphisa iintlungu zemilenze. Iingenelo eziqikelelweyo ze-HBOT ziquka ukunciphisa i-hypoxia kunye nokudumba, ukunciphisa ukuqokelelwa kwee-peptides ezibangela ukuvuvukala, kunye nokwandisa ukunamathela kwee-endorphins kwiindawo ze-receptor. Ngokuphucula iimeko ezisisiseko, i-HBOT inokunceda ukunciphisa iintlungu ezinxulumene nesifo semithambo yegazi ejikeleze imithambo yegazi.
Intloko ebuhlungu
Intloko ebuhlungu, ingakumbi i-migraines, ichazwa njengentlungu eyenzeka rhoqo echaphazela icala elinye lentloko, edla ngokuhamba nesicaphucaphu, ukuhlanza, kunye nokuphazamiseka kokubona. Ukuxhaphaka kwe-migraines minyaka le malunga ne-18% kwabasetyhini, i-6% kumadoda, kunye ne-4% kubantwana. Izifundo zibonisa ukuba i-oksijini inokunciphisa iintloko ezibuhlungu ngokunciphisa ukuhamba kwegazi ebuchotsheni. Unyango lwe-oksijini ye-hyperbaric lusebenza ngakumbi kunonyango lwe-oksijini ye-normobaric ekunyuseni amanqanaba e-oksijini egazini lemithambo yegazi kunye nokubangela ukuxinana okukhulu kwemithambo yegazi. Ke ngoko, i-HBOT ithathwa njengesebenza ngakumbi kunonyango lwe-oksijini oluqhelekileyo ekunyangeni ii-migraines.
Iintloko ezibuhlungu zeCluster
Ibonakala ngentlungu eqatha kakhulu ejikeleze iliso elinye, iintloko ezibuhlungu ezibangelwa ziikluster zihlala zihamba nokufakwa kwe-conjunctival, ukukrazula, ukuxinana kweempumlo, i-rhinorrhea, ukubila okuhlala kwindawo ethile, kunye nokudumba kwamehlo.Ukuphefumla ioksijini okwangoku kuthathwa njengendlela yonyango olukhawulezileyo lwentloko ebuhlungu yeqela.Iingxelo zophando zibonise ukuba unyango lwe-oksijini e-hyperbaric luluncedo kwizigulana ezingaphenduliyo kunyango lwe-pharmacological, nto leyo enciphisa ukuphindaphindeka kweziganeko zentlungu ezilandelayo. Ngenxa yoko, i-HBOT ayisebenzi kuphela ekulawuleni uhlaselo olukhawulezileyo kodwa ikwathintela ukwenzeka kweentloko ezibuhlungu kwixesha elizayo.
Isiphelo
Ngamafutshane, unyango lwe-oksijini e-hyperbaric lubonisa amandla abalulekileyo ekunciphiseni iintlobo ezahlukeneyo zentlungu yemisipha, kubandakanya iimeko ezifana ne-fibromyalgia syndrome, i-complex regional pain syndrome, i-myofascial pain syndrome, iintlungu ezinxulumene nesifo semithambo yegazi, kunye neentloko ezibuhlungu. Ngokujongana ne-localized hypoxia kunye nokukhuthaza ukuhanjiswa kweoksijini kwizicubu zemisipha, i-HBOT ibonelela ngenye indlela esebenzayo kwizigulana ezinesifo esingapheliyo esinganyangekiyo kwiindlela zonyango eziqhelekileyo. Njengoko uphando luqhubeka nokuphonononga ububanzi bokusebenza kakuhle konyango lwe-oksijini e-hyperbaric, luyindlela ethembisayo yokungenelela ekulawuleni iintlungu kunye nokunyamekela izigulana.
Ixesha leposi: Epreli-11-2025