Istroke, imeko ebuhlungu ebonakaliswa kukuncipha ngequbuliso kokunikezelwa kwegazi kwizicubu zobuchopho ngenxa yesifo sokopha okanye i-ischemic pathology, yeyona nto yesibini ebangela ukufa kwihlabathi liphela kwaye yeyona nto yesithathu ebangela ukukhubazeka. Iintlobo ezimbini eziphambili zestroke yi-ischemic stroke (eyi-68%) kunye ne-hemorrhagic stroke (32%). Nangona zingafani kwizigaba zokuqala, zombini ekugqibeleni zikhokelela ekunciphiseni kokunikezelwa kwegazi kunye ne-cerebral ischemia elandelayo ngexesha le-subacute kunye ne-chronic phases.
I-Ischemic Stroke
I-Ischemic stroke (AIS) iphawulwa kukuvaleka ngequbuliso komthambo wegazi, okubangela umonakalo we-ischemic kwindawo echaphazelekayo. Kwisigaba esikhawulezileyo, le ndawo iphambili ye-hypoxic ibangela uthotho lwe-excitotoxicity, uxinzelelo lwe-oxidative, kunye nokusebenza kwe-microglia, okukhokelela ekufeni okubanzi kwe-neuronal. Ngexesha lesigaba se-subacute, ukukhululwa kwe-cytokines, i-chemokines, kunye ne-matrix metalloproteinases (MMPs) kunokubangela ukudumba kwe-neuroinflammation. Okuphawulekayo kukuba, amanqanaba aphezulu e-MMPs anyusa ukungena komqobo wegazi-ubuchopho (BBB), okuvumela ukufuduka kwe-leukocyte ukuya kwindawo ethintelweyo, okwandisa umsebenzi wokuvuvukala.
Unyango lwangoku lwe-Ischemic Stroke
Unyango oluphambili olusebenzayo lwe-AIS luquka i-thrombolysis kunye ne-thrombectomy. I-thrombolysis ye-intravenous inokunceda izigulana kwiiyure ezi-4.5, apho unyango lwangethuba luthetha iingenelo ezinkulu. Xa kuthelekiswa ne-thrombolysis, i-thrombectomy yoomatshini inomnyango omkhulu wonyango. Ukongeza, unyango olungelulo olwezonyango, olungangenisi gazi olufana noluunyango lweoksijini, i-acupuncture, kunye nokuvuselelwa kombane ziya zithandwa njengonyango oluhambelana neendlela eziqhelekileyo.
Iziseko zoNyango lweOksijini yeHyperbaric (HBOT)
Kwinqanaba lolwandle (1 ATA = 101.3 kPa), umoya esiwuphefumlayo uqulathe malunga ne-21% yeoksijini. Phantsi kweemeko zebhayoloji, umlinganiselo weoksijini enyibilikisiweyo kwiplasma uncinci, malunga ne-0.29 mL (0.3%) kwi-100 mL yegazi. Phantsi kweemeko ze-hyperbaric, ukuphefumla i-100% yeoksijini kunyusa amanqanaba eoksijini enyibilikisiweyo kwiplasma kakhulu—ukuya kuthi ga kwi-3.26% kwi-1.5 ATA kunye ne-5.6% kwi-2.5 ATA. Ke ngoko, i-HBOT ijolise ekuphuculeni le nxalenye yeoksijini enyibilikisiweyo, ngempumelelo.Ukwanda koxinzelelo lweoksijini kwizicubu kwiindawo ezingasebenzi kakuhle. Xa uxinzelelo luphezulu, ioksijini isasazeka lula kwiizicubu ezingenayo ioksijini, ifikelela kumgama omde xa ithelekiswa noxinzelelo oluqhelekileyo lomoya.
Ukuza kuthi ga ngoku, i-HBOT ibone ukusetyenziswa ngokubanzi kwi-ischemic kunye ne-hemorrhagic stroke. Izifundo zibonisa ukuba i-HBOT inika iziphumo zokukhusela imithambo-luvo ngokusebenzisa iindlela ezininzi ezintsonkothileyo ze-molecular, biochemical, kunye ne-hemodynamic, kuquka:
1. Uxinzelelo oluncinci lweoksijini kwimithambo yegazi, nto leyo ephucula ukuhanjiswa kweoksijini kwizicubu zengqondo.
2. Ukuzinza kwe-BBB, ukunciphisa ukudumba kobuchopho.
3. Ukuphucula ubuchophoukujikeleza kwegazi kancinci, ukuphucula imetabolism yobuchopho kunye nemveliso yamandla ngelixa kugcinwa i-homeostasis yee-ion zeseli.
4. Ukulawula ukuhamba kwegazi ebuchotsheni ukunciphisa uxinzelelo lwangaphakathi kwentloko kunye nokunciphisa ukudumba kwengqondo.
5. Ukunciphisa ukudumba kwemithambo-luvo emva kwestroke.
6. Ukuthintela i-apoptosis kunye ne-necrosisemva kwestroke.
7. Ukunciphisa uxinzelelo lwe-oxidative kunye nokuthintela ukwenzakala kokuphinda kuphume igazi, okubaluleke kakhulu kwi-stroke pathophysiology.
8. Uphando lubonisa ukuba i-HBOT inokunciphisa i-vasospasm emva kwe-aneurysmal subarachnoid hemorrhage (SAH).
9. Ubungqina bukwaxhasa inzuzo ye-HBOT ekukhuthazeni i-neurogenesis kunye ne-angiogenesis.
Isiphelo
Unyango lwe-hyperbaric oxygen lunika indlela ethembisayo yokunyanga isifo sohlangothi. Njengoko siqhubeka nokusombulula iingxaki zokubuyela esiqhelweni, uphando olongezelelekileyo luya kuba yimfuneko ukuphucula ukuqonda kwethu ixesha, umthamo, kunye neendlela ze-HBOT.
Ngamafutshane, njengoko sihlola iingenelo zonyango lwe-hyperbaric oxygen kwi-stroke, kuyacaca ukuba ukusebenzisa olu nyango kunokubangela utshintsho kwindlela esiphatha ngayo i-ischemic stroke, kunika ithemba kwabo bachaphazelekileyo yile meko itshintsha ubomi.
Ukuba unomdla wokuhlola unyango lwe-hyperbaric oxygen njengonyango olunokwenzeka lokuchacha kwistroke, siyakumema ukuba undwendwele iwebhusayithi yethu ukuze ufunde okungakumbi malunga namagumbi ethu e-hyperbaric oxygen aphucukileyo. Ngoluhlu lweemodeli ezenzelwe ukusetyenziswa ekhaya nasemsebenzini, i-MACY-PAN inikezela ngezisombululo ezibonelela ngonyango lwe-oxygen olusemgangathweni ophezulu nolujolise ekuxhaseni uhambo lwakho lwempilo nolokubuyisela kwimeko yesiqhelo.
Fumanisa iimveliso zethu kunye nendlela ezinokuthi ziphucule ngayo impilo-ntle yakho aphawww.hbotmacypan.com.
Ixesha leposi: Feb-18-2025