I-Stroke, imeko eyingozi ebonakaliswe ngokuncipha ngokukhawuleza kwegazi kwiithishu zobuchopho ngenxa ye-hemorrhagic okanye i-ischemic pathology, yimbangela yesibini ehamba phambili yokufa kwihlabathi jikelele kunye nonobangela wesithathu okhokelayo wokukhubazeka. Iintlobo ezimbini eziphambili ze-stroke ziyi-ischemic stroke (i-accounting ye-68%) kunye ne-hemorrhagic stroke (32%). Nangona i-pathophysiology yabo eyahlukileyo kwizigaba zokuqala, zombini ekugqibeleni zikhokelela ekunciphiseni ukunikezelwa kwegazi kunye ne-cerebral ischemia elandelayo ngexesha le-subacute kunye nezigaba ezingapheliyo.
Ischemic Stroke
I-Ischemic stroke (AIS) ibonakaliswe ngokuvaleka ngokukhawuleza komthambo wegazi, okubangela umonakalo we-ischemic kwindawo echaphazelekayo. Kwinqanaba elibukhali, le ndawo iphambili ye-hypoxic ibangela i-cascade ye-excitotoxicity, uxinzelelo lwe-oxidative, kunye nokusebenza kwe-microglia, ekhokelela ekufeni okuxhaphakileyo kwe-neuronal. Ngexesha le-subacute phase, ukukhutshwa kwe-cytokines, i-chemokines, kunye ne-matrix metalloproteinases (MMPs) inokufaka isandla kwi-neuroinflammation. Ngokucacileyo, amanqanaba aphakanyisiweyo e-MMPs anyusa ukunyanzeliswa kwe-blood-brain barrier (BBB), evumela ukufuduka kwe-leukocyte kummandla we-infarcted, ukunyusa umsebenzi wokuvuvukala.
Unyango lwangoku lwe-Ischemic Stroke
Olona nyango lusebenzayo lwe-AIS lubandakanya i-thrombolysis kunye ne-thrombectomy. I-thrombolysis ye-Intravenous inokunceda izigulane kwiiyure ze-4.5, apho unyango lwakwangoko luguqulela kwiinzuzo ezinkulu. Xa kuthelekiswa ne-thrombolysis, i-thrombectomy yomatshini inefestile yonyango ebanzi. Ukongeza, unyango olungeyo-pharmacological, non-invasive ezifanaunyango lweoksijini, iacupuncture, kunye nokuvuselela umbane ziya zisiba nomtsalane njengonyango olongezelelekileyo kwiindlela eziqhelekileyo.
Izinto ezisisiseko zeHyperbaric Oxygen Therapy (HBOT)
Kumgangatho woxinzelelo lolwandle (1 ATA = 101.3 kPa), umoya esiwuphefumlayo ubandakanya malunga ne-21% ye-oxygen. Ngaphantsi kweemeko ze-physiological, umlinganiselo we-oksijini echithwe kwi-plasma encinci, kuphela malunga ne-0.29 mL (0.3%) nge-100 mL yegazi. Ngaphantsi kweemeko ze-hyperbaric, ukuphefumula i-100% i-oksijeni kwandisa amanqanaba e-oksijini echithwe kwi-plasma kakhulu-ukuya kwi-3.26% kwi-1.5 ATA kunye ne-5.6% kwi-2.5 ATA. Ke ngoko, i-HBOT ijolise ekuphuculeni le nxalenye yeoksijini enyibilikileyo, ngokufanelekileyoukwandisa ukugxininiswa kwe-oksijini ye-tissue kwimimandla ye-ischemic. Kuxinzelelo oluphezulu, ioksijini isasazeka ngokulula kwizicubu ze-hypoxic, ifikelela kumgama omde wokusasazwa xa kuthelekiswa noxinzelelo oluqhelekileyo lomoya.
Ukuza kuthi ga ngoku, i-HBOT ibone ukusetyenziswa ngokubanzi kuzo zombini izibetho ze-ischemic kunye ne-hemorrhagic. Uphononongo lubonisa ukuba i-HBOT inika iziphumo ze-neuroprotective ngokusebenzisa iimolekyuli ezininzi ezinzima, i-biochemical, kunye neendlela ze-hemodynamic, kuquka:
1. Ukwandisa uxinzelelo lwe-arterial oksijini inxalenye, ukuphucula ukuhanjiswa kwe-oksijini kwizicubu zengqondo.
2. Ukuzinziswa kwe-BBB, ukunciphisa i-edema yengqondo.
3. Ukomelezwa kobuchophomicrocirculation, ukuphucula imetabolism yobuchopho kunye nemveliso yamandla ngelixa ugcina i-homeostasis ye-cellular.
4. Ukulawulwa kokuhamba kwegazi kwi-cerebral ukunciphisa uxinzelelo lwe-intracranial kunye nokunciphisa ukudumba kwengqondo.
5. Ukunciphisa i-neuroinflammation post-stroke.
6. Ukunciphisa i-apoptosis kunye ne-necrosisisibetho esilandelayo.
7. Ukunciphisa uxinzelelo lwe-oxidative kunye nokuvinjelwa kokulimala ngokutsha, okubaluleke kakhulu kwi-stroke pathophysiology.
8. Uphando lucebisa ukuba i-HBOT inokunciphisa i-vasospasm elandela i-aneurysmal subarachnoid hemorrhage (SAH).
9. Ubungqina buxhasa kwakhona inzuzo ye-HBOT ekukhuthazeni i-neurogenesis kunye ne-angiogenesis.
Ukuqukumbela
Unyango lwe-oxygen ye-Hyperbaric ibonisa indlela ethembisayo yonyango lwe-stroke. Njengoko siqhubeka nokucacisa ubunzima bokubuyiswa kwe-stroke, uphando olongezelelweyo luya kuba luyimfuneko ekuphuculeni ukuqonda kwethu ixesha, umthamo, kunye neendlela ze-HBOT.
Isishwankathelo, njengoko sihlolisisa izibonelelo zonyango lwe-oxygen hyperbaric ngenxa ye-stroke, kuyacaca ukuba ukusebenzisa olu nyango lunamandla okuguqula indlela esilawula ngayo imivimbo ye-ischemic, ukuhambisa ithemba kulabo abachaphazelekayo kule meko yokuguqula ubomi.
Ukuba unomdla wokuphonononga unyango lwe-hyperbaric oxygen njengonyango olunokubakho lokubuyisela umva, siyakumema ukuba undwendwele iwebhusayithi yethu ukuze ufunde ngakumbi malunga namagumbi ethu aphezulu e-hyperbaric. Ngoluhlu lweemodeli ezilungiselelwe ukusetyenziswa kwekhaya kunye nobugcisa, i-MACY-PAN inikezela ngezisombululo ezinikezela ngekhwalithi ephezulu, unyango olujoliswe kwi-oksijini ukuxhasa impilo yakho kunye nohambo lokubuyisela.
Fumana iimveliso zethu kunye nendlela ezinokuthi ziphucule ngayo impilo yakhowww.hbotmacypan.com.
Ixesha lokuposa: Feb-18-2025