Kwicandelo lezonyango zanamhlanje, amayeza okubulala iintsholongwane abonakalise ukuba yenye yezona zinto ziphambili, ehlisa kakhulu izinga lokuxhaphaka nokufa okunxulunyaniswa nosulelo lweentsholongwane. Ukukwazi kwawo ukutshintsha iziphumo zonyango zosulelo lweentsholongwane kwandisa ixesha lokuphila kwezigulane ezininzi. Amayeza okubulala iintsholongwane abaluleke kakhulu kwiinkqubo zonyango ezintsonkothileyo, kubandakanya utyando, ukufakwa kwee-implants, ukufakelwa, kunye ne-chemotherapy. Nangona kunjalo, ukuvela kwezifo ezinganyangekiyo ngamayeza okubulala iintsholongwane kube yinto exhalabisayo, nto leyo enciphisa ukusebenza kwala mayeza ngokuhamba kwexesha. Iziganeko zokunganyangeki ngamayeza okubulala iintsholongwane zibhalwe kuzo zonke iindidi zamayeza okubulala iintsholongwane njengoko utshintsho lweentsholongwane lusenzeka. Uxinzelelo lokukhetha olukhutshwa ngamayeza okubulala iintsholongwane lube negalelo ekwandeni kweentlobo ezinganyangekiyo, nto leyo ebeka umngeni omkhulu kwimpilo yehlabathi.
Ukuze kuliwe nomba ongxamisekileyo wokuxhathisa iintsholongwane, kubalulekile ukuphumeza imigaqo-nkqubo esebenzayo yokulawula usulelo ethintela ukusasazeka kweentsholongwane ezinganyangekiyo, kunye nokunciphisa ukusetyenziswa kwee-antibiotics. Ngaphezu koko, kukho imfuneko engxamisekileyo yeendlela zonyango ezizezinye. Unyango lwe-Hyperbaric Oxygen (HBOT) luye lwavela njengendlela ethembisayo kule meko, equka ukuphefumla i-100% yeoksijini kumanqanaba athile oxinzelelo kangangexesha elithile. Ibekwe njengonyango oluphambili okanye oluhambelanayo lwezifo, i-HBOT inokunika ithemba elitsha ekunyangeni izifo ezibukhali ezibangelwa ziintsholongwane ezinganyangekiyo kwiintsholongwane.
Olu nyango lusetyenziswa ngakumbi njengonyango oluphambili okanye olulolunye kwiimeko ezahlukeneyo, kubandakanya ukudumba, ubuthi be-carbon monoxide, amanxeba angapheliyo, izifo ze-ischemic, kunye nosulelo. Ukusetyenziswa kwe-HBOT kunyango losulelo kukhulu, kubonelela ngeengenelo ezixabisekileyo kwizigulana.
Izicelo zeKlinikhi zeHyperbaric Oxygen Therapy kwiNtsholongwane
Ubungqina obukhoyo buxhasa ngamandla ukusetyenziswa kwe-HBOT, njengonyango oluzimeleyo noluncedisayo, nto leyo ebonisa iingenelo ezibalulekileyo kwizigulana ezineentsholongwane. Ngexesha le-HBOT, uxinzelelo lwe-oksijini yegazi olusemithanjeni lunokunyuka luye kwi-2000 mmHg, kwaye uxinzelelo oluphezulu lwe-oksijini-lwezicubu lunokunyusa amanqanaba e-oksijini kwizicubu ukuya kwi-500 mmHg. Ezi ziphumo zibaluleke kakhulu ekukhuthazeni ukuphiliswa kweempendulo zokudumba kunye nokuphazamiseka kwe-microcirculatory okubonwa kwiindawo ezinobungozi, kunye nokulawula i-compartment syndrome.
I-HBOT inokuchaphazela neemeko ezixhomekeke kwinkqubo yomzimba yokuzikhusela. Uphando lubonisa ukuba i-HBOT inokucinezela ii-autoimmune syndromes kunye neempendulo zomzimba ezibangelwa yi-antigen, inceda ukugcina ukunyamezelana kwe-graft ngokunciphisa ukujikeleza kwee-lymphocytes kunye nee-leukocytes ngelixa ilawula iimpendulo zomzimba. Ukongeza, i-HBOTixhasa ukuphiliswakwizilonda zesikhumba ezingapheliyo ngokuvuselela i-angiogenesis, inkqubo ebalulekileyo yokuphucula ukuchacha. Olu nyango lukwakhuthaza ukwakheka kwe-collagen matrix, isigaba esibalulekileyo ekuphilisweni kwenxeba.
Ingqwalasela ekhethekileyo kufuneka inikwe kwiintsholongwane ezithile, ingakumbi izifo ezinzulu nezinzima ukunyanga ezifana ne-necrotizing fasciitis, i-osteomyelitis, izifo ezingapheliyo zezicubu ezithambileyo, kunye ne-endocarditis esulelayo. Enye yezona ndlela ziqhelekileyo zokusetyenziswa kwe-HBOT kukwasulelwa kwezicubu ezithambileyo zesikhumba kunye ne-osteomyelitis enxulunyaniswa namanqanaba aphantsi eoksijini adla ngokubangelwa yintsholongwane engenamandla okanye enganyangekiyo.
1. Usulelo lweenyawo olubangelwa sisifo seswekile
Unyawo olunesifo seswekileIzilonda zixhaphakile phakathi kwezi zigulana ezineswekile, zichaphazela ukuya kuthi ga kwi-25% yale ndawo. Usulelo luhlala luvela kwezi zilonda (ezibalelwa kwi-40%-80% yamatyala) kwaye zikhokelela ekwandeni kokugula nokufa. Usulelo lweenyawo zeswekile (ii-DFI) ludla ngokuba nosulelo lweentsholongwane ezininzi kunye neentsholongwane ezahlukeneyo zebhaktheriya ezingabonakaliyo ezichongiweyo. Izinto ezahlukeneyo, kubandakanya iziphene zomsebenzi we-fibroblast, imiba yokwakheka kwe-collagen, iindlela zokuzikhusela zeeseli, kunye nomsebenzi we-phagocyte, zinokuthintela ukuphiliswa kwamanxeba kwizigulana ezineswekile. Izifundo ezininzi zichonge ukungasebenzi kakuhle kwe-oxygenation yesikhumba njengento enamandla enobungozi bokunqunyulwa kwamalungu anxulumene ne-DFIs.
Njengenye yeendlela ezikhoyo zonyango lwe-DFI, i-HBOT ibikwe ukuba inyusa kakhulu amazinga okuphiliswa kwezilonda zeenyawo zesifo seswekile, emva koko inciphisa isidingo sokunqunyulwa kwamalungu omzimba kunye nokungenelela okuntsonkothileyo kotyando. Ayinciphisi nje kuphela imfuneko yeenkqubo ezisebenzisa izixhobo ezininzi, ezinje ngotyando lwe-flap kunye nokufakelwa kwesikhumba, kodwa ikwabonelela ngeendleko eziphantsi kunye nemiphumo emibi encinci xa kuthelekiswa neendlela zotyando. Uphononongo lukaChen et al. lubonise ukuba iiseshoni ezingaphezu kwe-10 ze-HBOT zikhokelele ekuphucukeni kwama-78.3% kumazinga okuphiliswa kwenxeba kwizigulana ezinesifo seswekile.
2. Usulelo lweZicwili eziThambileyo oluNyukisayo
Usulelo lwezicubu ezithambileyo ezifunxayo (ii-NSTI) ludla ngokuba ziintsholongwane ezininzi, ezidla ngokuvela kudibaniso lwezifo zebhaktheriya ezibangela i-aerobic kunye ne-anaerobic kwaye zihlala zinxulunyaniswa nokuveliswa kwegesi. Nangona ii-NSTI zinqabile, zibonisa izinga eliphezulu lokufa ngenxa yokuqhubela phambili kwazo ngokukhawuleza. Ukuxilongwa ngexesha elifanelekileyo kunye nonyango zibalulekile ekufezekiseni iziphumo ezilungileyo, kwaye i-HBOT icetyisiwe njengendlela eyongezelelweyo yokulawula ii-NSTI. Nangona kusekho impikiswano malunga nokusetyenziswa kwe-HBOT kwii-NSTI ngenxa yokungabikho kwezifundo ezilawulwayo ezinokubakho,ubungqina bubonisa ukuba oku kunokunxulunyaniswa namazinga okusinda aphucukileyo kunye nokugcinwa kwamalungu omzimba kwizigulane ze-NSTIUphononongo olujonga emva lubonise ukwehla okukhulu kwamazinga okufa phakathi kwezigulane ze-NSTI ezifumana i-HBOT.
1.3 Usulelo kwindawo yotyando
Ii-SSIs zinokuhlulwahlulwa ngokusekelwe kwindawo yokwakheka kosulelo kwaye zinokuvela kwiintsholongwane ezahlukeneyo, kuquka zombini iintsholongwane ze-aerobic kunye ne-anaerobic. Nangona kukho inkqubela phambili kumanyathelo okulawula usulelo, njengeendlela zokubulala iintsholongwane, ukusetyenziswa kwee-antibiotics zokuthintela, kunye nokuphucula iindlela zotyando, ii-SSIs zihlala ziyingxaki eqhubekayo.
Olunye uphononongo olubalulekileyo luphande ukusebenza kakuhle kwe-HBOT ekuthinteleni ii-SSI ezinzulu kutyando lwe-neuromuscular scoliosis. I-HBOT yangaphambi kotyando inokunciphisa kakhulu ukwanda kwee-SSI kwaye incede ukuphiliswa kwamanxeba. Olu nyango lungangenisi mzimba ludala imeko apho amanqanaba eoksijini kwizicubu zamanxeba enyuka, nto leyo enxulunyaniswa nesenzo sokubulala i-oxidative ngokuchasene nezifo ezibangelwa ziintsholongwane. Ukongeza, ijongana namanqanaba egazi kunye neoksijini aphantsi anegalelo ekuphuhlisweni kwee-SSI. Ngaphandle kwezinye iindlela zokulawula usulelo, i-HBOT icetyisiwe ngakumbi kwiindlela zotyando ezicocekileyo ezifana neenkqubo ze-colorectal.
1.4 Ukutsha
Ukutsha kukwenzakala okubangelwa bubushushu obugqithisileyo, umbane, iikhemikhali, okanye imitha kwaye kunokubangela amazinga aphezulu okugula nokufa. I-HBOT iluncedo ekunyangeni ukutsha ngokunyusa amanqanaba eoksijini kwizicubu ezonakeleyo. Ngelixa izifundo zezilwanyana nezeklinikhi zibonisa iziphumo ezixubeneyo malungaukusebenza kakuhle kwe-HBOT kunyango lokutsha, uphando olubandakanya izigulana ezili-125 ezitshileyo lubonise ukuba i-HBOT ayibonisanga mpembelelo ibalulekileyo kwizinga lokufa okanye kwinani lotyando olwenziweyo kodwa inciphise ixesha eliqhelekileyo lokuphiliswa (iintsuku ezili-19.7 xa kuthelekiswa neentsuku ezingama-43.8). Ukudibanisa i-HBOT nolawulo olupheleleyo lokutsha kunokulawula ngempumelelo i-sepsis kwizigulana ezitshileyo, nto leyo ekhokelela kwixesha elifutshane lokuphiliswa kunye nokuncipha kweemfuno zolwelo. Nangona kunjalo, uphando oluthe kratya oluqhubekayo luyafuneka ukuqinisekisa indima ye-HBOT kulawulo lokutsha kakhulu.
1.5 I-Osteomyelitis
I-Osteomyelitis lusulelo lwethambo okanye umongo wethambo oludla ngokubangelwa zizifo ezibangelwa ziintsholongwane. Ukunyanga i-osteomyelitis kunokuba nzima ngenxa yokunikezelwa kwegazi okuncinci emathanjeni kunye nokungena okuncinci kwee-antibiotics kumongo. I-osteomyelitis engapheliyo ibonakaliswa ziintsholongwane ezihlala zihleli, ukudumba okuncinci, kunye nokwakheka kwezicubu zamathambo ezifileyo. I-osteomyelitis engapheliyo ibhekisa kwiintsholongwane zamathambo ezingapheliyo eziqhubeka okanye eziphinda-phinda nangona unyango olufanelekileyo lufanelekile.
I-HBOT ibonakalisiwe ukuba iphucula kakhulu amanqanaba eoksijini kwizicubu zamathambo ezinesi sifo. Uthotho lwamatyala amaninzi kunye nezifundo zamaqela zibonisa ukuba i-HBOT iphucula iziphumo zonyango kwizigulane ze-osteomyelitis. Kubonakala ngathi isebenza ngeendlela ezahlukeneyo, kubandakanya ukukhulisa umsebenzi we-metabolic, ukucinezela iintsholongwane, ukuphucula iziphumo ze-antibiotic, ukunciphisa ukudumba, kunye nokukhuthaza ukuphiliswa.iinkqubo. Emva kwe-HBOT, ama-60% ukuya kuma-85% ezigulana ezine-osteomyelitis engapheliyo nengaguqukiyo zibonisa iimpawu zokuthintelwa kosulelo.
1.6 Usulelo lweMikhuhlane
Ehlabathini jikelele, abantu abangaphezu kwezigidi ezithathu bahlushwa zizifo ezingapheliyo okanye ezihlaselayo zefungus, nto leyo ekhokelela ekufeni kwabantu abangaphezu kwama-600,000 ngonyaka. Iziphumo zonyango lwezifo ezihlaselayo zefungus zihlala zichaphazeleka ngenxa yezinto ezifana nokutshintsha kwesimo somzimba, izifo ezisisiseko, kunye neempawu zobungozi be-pathogen. I-HBOT iba lukhetho olunomtsalane lonyango kwizifo ezihlaselayo zefungus ngenxa yokhuseleko lwayo kunye nokungabi nazo. Izifundo zibonisa ukuba i-HBOT ingasebenza ngokuchasene nezifo ezihlaselayo zefungus ezifana ne-Aspergillus kunye nesifo sephepha iMycobacterium.
I-HBOT ikhuthaza iziphumo zokubola ngokuthintela ukwakheka kwe-biofilm ye-Aspergillus, kwaye ukusebenza kakuhle kuphawulwe kwiintlobo ezingenazo iijini ze-superoxide dismutase (SOD). Iimeko ezinobungozi ngexesha losulelo lwefungus zibangela imingeni ekuhanjisweni kwamayeza okubola, okwenza amanqanaba aphezulu eoksijini evela kwi-HBOT abe luncedo, nangona uphando olongezelelweyo lufanelekile.
Iimpawu ze-HBOT ze-Antimicrobial
Indawo enobungozi obuphezulu eyenziwe yi-HBOT iqala utshintsho lwe-physiological kunye ne-biochemical oluvuselela iipropati ze-antibacterial, nto leyo eyenza ukuba ibe lunyango olusebenzayo lokuncedisa usulelo. I-HBOT ibonisa iziphumo eziphawulekayo ngokuchasene neebhaktheriya ze-aerobic kunye neebhaktheriya ezingena-aerobic ikakhulu ngeendlela ezifana nomsebenzi othe ngqo we-bacterial, ukuphucula iimpendulo zomzimba, kunye neziphumo ze-synergistic kunye nee-arhente ezithile ze-antimicrobial.
2.1 Imiphumo ethe ngqo ye-HBOT ye-Antibacterial
Isiphumo esithe ngqo se-HBOT sokulwa neentsholongwane sibangelwa kakhulu kukuveliswa kweentlobo ze-oxygen ezisabelayo (i-ROS), eziquka ii-superoxide anions, i-hydrogen peroxide, ii-hydroxyl radicals, kunye nee-hydroxyl ions—zonke ezithi zivele ngexesha le-metabolism yeseli.
Ukusebenzisana phakathi kwe-O₂ kunye nezinto zeseli kubalulekile ekuqondeni indlela i-ROS eyakheka ngayo ngaphakathi kweeseli. Phantsi kweemeko ezithile ezibizwa ngokuba yi-oxidative stress, ibhalansi phakathi kokwakheka kwe-ROS kunye nokuwohloka kwayo iyaphazamiseka, nto leyo ekhokelela kumanqanaba aphezulu e-ROS kwiiseli. Ukuveliswa kwe-superoxide (O₂⁻) kukhuthazwa yi-superoxide dismutase, ethi kamva iguqule i-O₂⁻ ibe yi-hydrogen peroxide (H₂O₂). Olu tshintsho lukhuliswa ngakumbi yi-Fenton reaction, ekhupha i-Fe²⁺ ukuvelisa ii-hydroxyl radicals (·OH) kunye ne-Fe³⁺, ngaloo ndlela iqalisa ulandelelwano olubi lwe-redox lokwakheka kwe-ROS kunye nomonakalo weseli.
Iziphumo zetyhefu zeROS zijolise kwizixhobo ezibalulekileyo zeseli ezifana neDNA, iRNA, iiproteni, kunye neelipids. Okuphawulekayo kukuba, iDNA yeyona nto iphambili ekujoliswe kuyo yi-H₂O₂-mediated cytotoxicity, njengoko iphazamisa izakhiwo ze-deoxyribose kwaye yonakalisa ukwakheka kwesiseko. Umonakalo obangelwa yiROS ufikelela kwisakhiwo se-helix seDNA, esinokubangelwa yi-lipid peroxidation ebangelwa yiROS. Oku kugxininisa imiphumo emibi yamanqanaba aphezulu eROS kwiinkqubo zebhayoloji.
Isenzo se-ROS sokulwa neentsholongwane
I-ROS idlala indima ebalulekileyo ekuthinteleni ukukhula kweentsholongwane, njengoko kubonisiwe ngokuveliswa kwe-ROS ebangelwa yi-HBOT. Iziphumo ezinobungozi ze-ROS zijolise ngqo kwizinto zeseli ezifana ne-DNA, iiproteni, kunye nee-lipids. Uxinzelelo oluphezulu lweentlobo zeoksijini ezisebenzayo lunokonakalisa ngokuthe ngqo ii-lipids, nto leyo ekhokelela ekufakweni kwe-lipid peroxidation. Le nkqubo ibeka emngciphekweni ukuthembeka kwee-membranes zeseli, kwaye ngenxa yoko, ukusebenza kwee-receptors kunye neeproteni ezinxulumene ne-membrane.
Ngaphezu koko, iiproteni, ezikwayizona njongo zibalulekileyo ze-ROS molecular, zitshintshatshintsha i-oxidative kwii-amino acid residues ezahlukeneyo ezifana ne-cysteine, i-methionine, i-tyrosine, i-phenylalanine, kunye ne-tryptophan. Umzekelo, i-HBOT ibonakalisiwe ukuba ibangela utshintsho lwe-oxidative kwiiproteni ezininzi kwi-E. coli, kubandakanya i-elongation factor G kunye ne-DnaK, ngaloo ndlela ichaphazela imisebenzi yazo yeseli.
Ukuphucula Ukuzikhusela Kwi-HBOT
Iimpawu ze-HBOT zokulwa nokuvuvukalaziye zabhalwa phantsi, nto leyo engqineka ibalulekile ekunciphiseni umonakalo wezicubu kunye nokuthintela ukuqhubeka kosulelo. I-HBOT ichaphazela kakhulu ukubonakaliswa kwee-cytokines kunye nezinye izilawuli zokuvuvukala, ichaphazela impendulo yomzimba. Iinkqubo ezahlukeneyo zovavanyo zibone utshintsho olwahlukileyo ekubonakalisweni kwezakhi zofuzo kunye nokuveliswa kweeproteni emva kwe-HBOT, ezithi zinyuse okanye zinciphise izinto zokukhula kunye nee-cytokines.
Ngexesha lenkqubo ye-HBOT, ukunyuka kwamanqanaba e-O₂ kubangela iimpendulo ezahlukeneyo zeeseli, ezinje ngokucinezela ukukhululwa kwezinto ezibangela ukudumba kunye nokukhuthaza i-lymphocyte kunye ne-neutrophil apoptosis. Ezi zenzo zizonke ziphucula iindlela zokulwa neentsholongwane zenkqubo yomzimba yokuzikhusela, ngaloo ndlela zinceda ukuphiliswa kwezifo.
Ngaphezu koko, izifundo zibonisa ukuba ukunyuka kwamanqanaba e-O₂ ngexesha le-HBOT kunokunciphisa ukubonakaliswa kwee-cytokines ezibangela ukuvuvukala, kubandakanya i-interferon-gamma (IFN-γ), i-interleukin-1 (IL-1), kunye ne-interleukin-6 (IL-6). Olu tshintsho lukwabandakanya ukunciphisa umlinganiselo weeseli ze-CD4:CD8 T kunye nokuguqula ezinye ii-receptors ezinyibilikayo, ekugqibeleni kunyuswe amanqanaba e-interleukin-10 (IL-10), nto leyo ibalulekileyo ekulweni nokuvuvukala kunye nokukhuthaza ukuphiliswa.
Imisebenzi ye-HBOT yokulwa neentsholongwane idibene neendlela ezintsonkothileyo zebhayoloji. Zombini i-superoxide kunye noxinzelelo oluphezulu ziye zaxelwa ukuba zikhuthaza ngokungaguqukiyo umsebenzi we-antibacterial obangelwa yi-HBOT kunye ne-neutrophil apoptosis. Emva kwe-HBOT, ukunyuka okuphawulekayo kwamanqanaba eoksijini kuphucula amandla okubulala iintsholongwane ee-neutrophils, into ebalulekileyo kwimpendulo yomzimba. Ngaphezu koko, i-HBOT iyayicinezela i-neutrophil adhesion, elawulwa kukusebenzisana kwe-β-integrins kwi-neutrophils kunye neemolekyuli ze-intercellular adhesion (ICAM) kwiiseli ze-endothelial. I-HBOT iyayithintela imisebenzi ye-neutrophil β-2 integrin (Mac-1, CD11b/CD18) ngenkqubo exhaswa yi-nitric oxide (NO), enegalelo ekufudukeleni kwee-neutrophils kwindawo yosulelo.
Ukulungiswa kwakhona ngokuchanekileyo kwe-cytoskeleton kuyimfuneko kwii-neutrophils ukuze zikwazi ukubulala iintsholongwane ngempumelelo. I-S-nitrosylation ye-actin ibonakalisiwe ukuba ivuselela i-actin polymerization, nto leyo enokubangela ukuba i-phagocytic activity yee-neutrophils emva konyango lwe-HBOT iqhubeke. Ngaphezu koko, i-HBOT ikhuthaza i-apoptosis kwimigca yeeseli ze-T zabantu ngeendlela ze-mitochondrial, kunye nokufa kwe-lymphocyte okukhawulezileyo emva kwe-HBOT kuxelwe. Ukuthintela i-caspase-9—ngaphandle kokuchaphazela i-caspase-8—kuye kwabonisa iziphumo ze-immunomodulatory ze-HBOT.
Iziphumo ze-Synergistic ze-HBOT kunye nee-Antimicrobial Agents
Kwizicelo zonyango, i-HBOT isetyenziswa rhoqo kunye nee-antibiotics ukulwa nosulelo ngempumelelo. Imeko ye-hyperoxic efikelelwayo ngexesha le-HBOT inokuchaphazela ukusebenza kwee-arhente ezithile ze-antibiotic. Uphando lubonisa ukuba amayeza athile okubulala iintsholongwane, anjenge-β-lactams, i-fluoroquinolones, kunye ne-aminoglycosides, awasebenzi nje kuphela ngeendlela ezingokwemvelo kodwa axhomekeke nakwi-aerobic metabolism yebhaktiriya. Ke ngoko, ubukho beoksijini kunye neempawu ze-metabolic ze-pathogens zibalulekile xa kuvavanywa iziphumo zonyango ze-antibiotics.
Ubungqina obubalulekileyo bubonise ukuba amanqanaba aphantsi eoksijini anokunyusa ukumelana kwePseudomonas aeruginosa kwi-piperacillin/tazobactam kwaye indawo eneoksijini ephantsi ikwanegalelo ekuchaseni okwandisiweyo kwe-Enterobacter cloacae kwi-azithromycin. Ngokwahlukileyo koko, ezinye iimeko ze-hypoxia zinokunyusa uvakalelo lwebhaktheriya kwii-antibiotics ze-tetracycline. I-HBOT isebenza njengendlela yonyango esebenzayo ngokukhuthaza imetabolism ye-aerobic kunye nokubuyisela ioksijini kwiithishu ezine-hypoxia, emva koko zonyusa uvakalelo lwezifo kwii-antibiotics.
Kwizifundo zangaphambi konyango, indibaniselwano ye-HBOT—enikwa kabini ngemini iiyure ezisi-8 kwi-280 kPa—kunye ne-tobramycin (20 mg/kg/ngosuku) inciphise kakhulu umthwalo weebhaktheriya kwi-Staphylococcus aureus infectious endocarditis. Oku kubonisa amandla e-HBOT njengonyango oluncedisayo. Uphando olongezelelekileyo lutyhile ukuba phantsi koxinzelelo lwe-37°C kunye ne-3 ATA iiyure ezi-5, i-HBOT yonyusa kakhulu imiphumo ye-imipenem ngokuchasene ne-Pseudomonas aeruginosa enesifo se-macrophage. Ukongeza, indlela edibeneyo ye-HBOT kunye ne-cephazolin ifunyenwe isebenza ngakumbi ekunyangeni i-Staphylococcus aureus osteomyelitis kwiimodeli zezilwanyana xa kuthelekiswa ne-cephazolin yodwa.
I-HBOT ikwanyusa kakhulu isenzo se-ciprofloxacin sokubulala iintsholongwane kwi-Pseudomonas aeruginosa biofilms, ingakumbi emva kwemizuzu engama-90 yokuvezwa. Olu phuculo lubangelwa kukwenziwa kweentlobo ze-oxygen reactive oxygen (ROS) kwaye lubonisa uvakalelo oluphezulu kwiinguqu ezine-peroxidase.
Kwiimodeli ze-pleuritis ezibangelwa yi-methicillin-resistant Staphylococcus aureus (MRSA), isiphumo sokusebenzisana kwe-vancomycin, i-teicoplanin, kunye ne-linezolid kunye ne-HBOT sibonise ukwanda okukhulu kokusebenza ngokuchasene ne-MRSA. I-Metronidazole, i-antibiotic esetyenziswa kakhulu ekunyangeni usulelo olunzima lwe-anaerobic kunye ne-polymicrobial ezifana nosulelo lweenyawo zesifo seswekile (DFIs) kunye nosulelo lwendawo yotyando (SSIs), ibonakalise ukusebenza okuphezulu kwe-antimicrobial phantsi kweemeko ze-anaerobic. Izifundo zexesha elizayo ziyafuneka ukuze kuhlolwe iziphumo ze-antibacterial ze-HBOT ezidityaniswe ne-metronidazole kokubini kwi-in vivo nakwi-in vitro.
Ukusebenza kwe-HBOT kwi-antimicrobial kwiibhaktheriya ezichaseneyo
Ngenxa yokuguquka nokwanda kweentlobo ezichaseneyo, amayeza okubulala iintsholongwane emveli adla ngokulahlekelwa ngamandla awo ngokuhamba kwexesha. Ngaphezu koko, i-HBOT inokuba luncedo ekunyangeni nasekuthinteleni usulelo olubangelwa ziintsholongwane ezichasene namayeza amaninzi, isebenza njengecebo elibalulekileyo xa unyango lwamayeza okubulala iintsholongwane lungaphumeleli. Izifundo ezininzi zibike ngemiphumo ebalulekileyo yokubulala iintsholongwane ye-HBOT kwiintsholongwane ezichaseneyo nezonyango. Umzekelo, iseshoni ye-HBOT yemizuzu engama-90 kwi-2 ATM inciphise kakhulu ukukhula kwe-MRSA. Ukongeza, kwiimodeli zomlinganiselo, i-HBOT iphucule imiphumo yokulwa neentsholongwane ye-antibiotics ezahlukeneyo nxamnye nosulelo lwe-MRSA. Iingxelo ziqinisekisile ukuba i-HBOT iyasebenza ekunyangeni i-osteomyelitis ebangelwa yi-Klebsiella pneumoniae evelisa i-OXA-48 ngaphandle kokufuna naziphi na ii-antibiotics ezongezelelweyo.
Ngamafutshane, unyango lwe-hyperbaric oxygen lumele indlela eneenkalo ezininzi yokulawula usulelo, luphucula impendulo yomzimba ngelixa lukwaphucula ukusebenza kakuhle kwee-antimicrobial agents ezikhoyo. Ngophando olupheleleyo nophuhliso, lunamandla okunciphisa imiphumo yokunganyangeki kwee-antibiotic, lunika ithemba kwidabi eliqhubekayo nxamnye nosulelo lweebhaktheriya.
Ixesha leposi: Feb-28-2025